BDBM481161 6-((5S,8R)-2-(6-Methylpyridin-2-yl)-5,6,7,8-tetrahydro-5,8-methanoimidazo[1,2-a]pyridin-3-yl)[1,2,4]triazolo[4,3-a]pyridine-3-carboxamide 2-1::US10906905, Example 2-1

SMILES Cc1cccc(n1)-c1nc2[C@@H]3CC[C@@H](C3)n2c1-c1ccc2nnc(C(N)=O)n2c1

InChI Key InChIKey=BKVNNKVIKPHFKN-OCCSQVGLSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 481161   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481161(6-((5S,8R)-2-(6-Methylpyridin-2-yl)-5,6,7,8-tetrah...)
Affinity DataIC50:  3nMAssay Description:TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481161(6-((5S,8R)-2-(6-Methylpyridin-2-yl)-5,6,7,8-tetrah...)
Affinity DataIC50:  1.71E+3nMAssay Description:p38α kinase assay kit (V9591, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481161(6-((5S,8R)-2-(6-Methylpyridin-2-yl)-5,6,7,8-tetrah...)
Affinity DataIC50:  1.16E+3nMAssay Description:VEGFR2: Z′-LYTE® Kinase Assay Kit—Tyrosine 1 Peptide (PV3190, Invitrogen) was used to assay enzyme activity. 5 μl of recombinant human VEG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent