BDBM481186 US10906905, Example 9-2

SMILES NC(=O)c1nnc2ccc(cn12)-c1c(nc2[C@H]3CC[C@H](C3)n12)-c1ccc(F)cn1

InChI Key InChIKey=KZNQXFBFJRDXTF-GXFFZTMASA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 481186   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481186(US10906905, Example 9-2)
Affinity DataIC50:  13nMAssay Description:TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481186(US10906905, Example 9-2)
Affinity DataIC50:  2.46E+3nMAssay Description:p38α kinase assay kit (V9591, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481186(US10906905, Example 9-2)
Affinity DataIC50:  1.35E+3nMAssay Description:VEGFR2: Z′-LYTE® Kinase Assay Kit—Tyrosine 1 Peptide (PV3190, Invitrogen) was used to assay enzyme activity. 5 μl of recombinant human VEG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent