BDBM481193 4-(2-(6-Methylpyridin-2-yl)-4,5,6,7-tetrahydro-4,7-ethanopyrazolo[1,5-a]pyridin-3-yl)quinoline-6-carboxamide 34::US10906905, Example 34

SMILES Cc1cccc(n1)-c1nn2C3CCC(CC3)c2c1-c1ccnc2ccc(cc12)C(N)=O

InChI Key InChIKey=WXDFWGNBHNFNIF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 481193   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481193(4-(2-(6-Methylpyridin-2-yl)-4,5,6,7-tetrahydro-4,7...)
Affinity DataIC50:  1.24E+3nMAssay Description:VEGFR2: Z′-LYTE® Kinase Assay Kit—Tyrosine 1 Peptide (PV3190, Invitrogen) was used to assay enzyme activity. 5 μl of recombinant human VEG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481193(4-(2-(6-Methylpyridin-2-yl)-4,5,6,7-tetrahydro-4,7...)
Affinity DataIC50:  12nMAssay Description:TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent