BDBM481201 (5S,8R)-2-(5-Fluoropyridin-2-yl)-3-(2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)-5,6,7,8-tetrahydro-5,8-methanoimidazo[1,2-a]pyridine 40-1::US10906905, Example 40-1

SMILES Cn1cc(cn1)-c1cc(ccn1)-c1c(nc2[C@@H]3CC[C@@H](C3)n12)-c1ccc(F)cn1

InChI Key InChIKey=OKJBNDABXTVZHD-PBHICJAKSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 481201   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481201((5S,8R)-2-(5-Fluoropyridin-2-yl)-3-(2-(1-methyl-1H...)
Affinity DataIC50:  10nMAssay Description:TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481201((5S,8R)-2-(5-Fluoropyridin-2-yl)-3-(2-(1-methyl-1H...)
Affinity DataIC50:  1.36E+3nMAssay Description:p38α kinase assay kit (V9591, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481201((5S,8R)-2-(5-Fluoropyridin-2-yl)-3-(2-(1-methyl-1H...)
Affinity DataIC50:  2.08E+3nMAssay Description:VEGFR2: Z′-LYTE® Kinase Assay Kit—Tyrosine 1 Peptide (PV3190, Invitrogen) was used to assay enzyme activity. 5 μl of recombinant human VEG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent