BDBM481204 2-(6-Methylpyridin-2-yl)-3-(2-(1-(methylsulfonyl)-1H-pyrazol-4-yl)pyridin-4-yl)-5, 6,7,8-tetrahydro-5,8-methanoimidazo[1,2-a]pyridine 43::US10906905, Example 43

SMILES Cc1cccc(n1)-c1nc2C3CCC(C3)n2c1-c1ccnc(c1)-c1cnn(c1)S(C)(=O)=O

InChI Key InChIKey=MMWRLDUOCZWADE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 481204   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481204(2-(6-Methylpyridin-2-yl)-3-(2-(1-(methylsulfonyl)-...)
Affinity DataIC50:  551nMAssay Description:VEGFR2: Z′-LYTE® Kinase Assay Kit—Tyrosine 1 Peptide (PV3190, Invitrogen) was used to assay enzyme activity. 5 μl of recombinant human VEG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481204(2-(6-Methylpyridin-2-yl)-3-(2-(1-(methylsulfonyl)-...)
Affinity DataIC50:  21nMAssay Description:TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent