BDBM481390 US10906915, Ex. 185::[(2R)-3-(3-ethyl-4-oxo- spiro[6,8-dihydro-5H- pyrazolo[4,3-c]azepine- 7,4'-tetrahydropyran]-1-yl)- 2-methyl-propyl] 4-cyano- 3-fluoro-benzoate

SMILES CCc1nn(C[C@@H](C)COC(=O)c2ccc(C#N)c(F)c2)c2CC3(CCOCC3)CNC(=O)c12

InChI Key InChIKey=GMQCQEJIICLFOS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 481390   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Leo Pharma

US Patent
LigandPNGBDBM481390([(2R)-3-(3-ethyl-4-oxo- spiro[6,8-dihydro-5H- pyra...)
Affinity DataIC50: 100nMAssay Description:The human PDE4D catalytic domain (UniProt no. Q08499 [5380-L740]) was incubated with a mixture of non-labelled cAMP (cyclic adenosine monophosphate) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent