BDBM482234 4-ethyl-5,11-dihydro- 4H-3,4,10,11-::US10918645, Example 32::US10918645, Example 46

SMILES CCn1c2nccc3[nH]nc(c23)c2ccccc2c1=O

InChI Key InChIKey=ATCPOUIMRFFNGD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 482234   

LigandPNGBDBM482234(US10918645, Example 46 | 4-ethyl-5,11-dihydro- 4H-...)
Affinity DataIC50: 34nMAssay Description:TTBK1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 1 mg/ml BSA, 10 mM DTT) is assayed against RRKDLHDDEEDEAMSITA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2021
Entry Details
US Patent

LigandPNGBDBM482234(US10918645, Example 46 | 4-ethyl-5,11-dihydro- 4H-...)
Affinity DataIC50: 49nMAssay Description:TTBK1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 1 mg/ml BSA, 10 mM DTT) is assayed against RRKDLHDDEEDEAMSITA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Lifearc

US Patent
LigandPNGBDBM482234(US10918645, Example 46 | 4-ethyl-5,11-dihydro- 4H-...)
Affinity DataIC50: 1.90E+3nMAssay Description:JAK2 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.05% 0-mercaptoethanol, 1 mg/ml BSA) is assayed against PDKtide (KTFCGTPEYLAPEVRREPRILSEEEQ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2021
Entry Details
US Patent