BDBM482236 4-cyclopropyl-5,11-dihydro-4H- 3,4,10,11-tetraazadibenzo[cd,h] azulene::US10918645, Example 33::US10918645, Example 47

SMILES O=c1n(C2CC2)c2nccc3[nH]nc(c23)c2ccccc12

InChI Key InChIKey=TYIBIYFVMDSKGS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 482236   

LigandPNGBDBM482236(US10918645, Example 47 | US10918645, Example 33 | ...)
Affinity DataIC50: 30nMAssay Description:TTBK1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 1 mg/ml BSA, 10 mM DTT) is assayed against RRKDLHDDEEDEAMSITA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2021
Entry Details
US Patent

LigandPNGBDBM482236(US10918645, Example 47 | US10918645, Example 33 | ...)
Affinity DataIC50: 54nMAssay Description:TTBK1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 1 mg/ml BSA, 10 mM DTT) is assayed against RRKDLHDDEEDEAMSITA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Lifearc

US Patent
LigandPNGBDBM482236(US10918645, Example 47 | US10918645, Example 33 | ...)
Affinity DataIC50: 2.20E+3nMAssay Description:JAK2 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.05% 0-mercaptoethanol, 1 mg/ml BSA) is assayed against PDKtide (KTFCGTPEYLAPEVRREPRILSEEEQ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2021
Entry Details
US Patent