BDBM482254 4-(1-isopropylpiperidin- 4-yl)-5,11- dihydro-4H-3,4,10,11- tetraazadibenzo[cd,h]azulene::US10918645, Example 56

SMILES CC(C)N1CCC(CC1)n1c2nccc3[nH]nc(c23)c2ccccc2c1=O

InChI Key InChIKey=HZGILNNSWAONEI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 482254   

LigandPNGBDBM482254(US10918645, Example 56 | 4-(1-isopropylpiperidin- ...)
Affinity DataIC50: 58nMAssay Description:TTBK1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 1 mg/ml BSA, 10 mM DTT) is assayed against RRKDLHDDEEDEAMSITA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Lifearc

US Patent
LigandPNGBDBM482254(US10918645, Example 56 | 4-(1-isopropylpiperidin- ...)
Affinity DataIC50: 4.80E+3nMAssay Description:JAK2 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.05% 0-mercaptoethanol, 1 mg/ml BSA) is assayed against PDKtide (KTFCGTPEYLAPEVRREPRILSEEEQ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
US Patent