BDBM482281 2-isopropyl-9-(tetrahydro-2H- pyran-4-yl)-2,5,9,10-tetrahydro-1,2, 4,5,8,9-hexaazabenzo [cd]cyclopenta[h]azulene::US10918645, Example 74

SMILES CC(C)n1cc-2c(CN(C3CCOCC3)c3nccc4[nH]nc-2c34)n1

InChI Key InChIKey=AOAAIUCYRQKVJY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 482281   

LigandPNGBDBM482281(US10918645, Example 74 | 2-isopropyl-9-(tetrahydro...)
Affinity DataIC50: 50nMAssay Description:TTBK1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 1 mg/ml BSA, 10 mM DTT) is assayed against RRKDLHDDEEDEAMSITA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Lifearc

US Patent
LigandPNGBDBM482281(US10918645, Example 74 | 2-isopropyl-9-(tetrahydro...)
Affinity DataIC50: 2.40E+3nMAssay Description:JAK2 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.05% 0-mercaptoethanol, 1 mg/ml BSA) is assayed against PDKtide (KTFCGTPEYLAPEVRREPRILSEEEQ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
US Patent