BDBM482288 8-ethyl-4-(tetrahydro-2H-pyran-4- yl)-5,11-dihydro-4H-3,4,7,10,11- pentaazadibenzo[cd,h]azulene::US10918645, Example 91

SMILES CCc1cc2-c3n[nH]c4ccnc(N(Cc2cn1)C1CCOCC1)c34

InChI Key InChIKey=WCXBXNOUAHQVEK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 482288   

LigandPNGBDBM482288(US10918645, Example 91 | 8-ethyl-4-(tetrahydro-2H-...)
Affinity DataIC50: 6nMAssay Description:TTBK1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 1 mg/ml BSA, 10 mM DTT) is assayed against RRKDLHDDEEDEAMSITA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Lifearc

US Patent
LigandPNGBDBM482288(US10918645, Example 91 | 8-ethyl-4-(tetrahydro-2H-...)
Affinity DataIC50: 1.70E+3nMAssay Description:JAK2 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.05% 0-mercaptoethanol, 1 mg/ml BSA) is assayed against PDKtide (KTFCGTPEYLAPEVRREPRILSEEEQ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
US Patent