BDBM482289 1-isopropyl-9-(1-(2-methoxyethyl) piperidin-4-yl)-1,5,9,10-tetra- hydro-1,2,4,5,8,9- hexaazabenzo[cd]cyclopenta[h]azulene::US10918645, Example 84

SMILES COCCN1CCC(CC1)N1Cc2c(cnn2C(C)C)-c2n[nH]c3ccnc1c23

InChI Key InChIKey=UOQZUVUTYBJAMY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 482289   

LigandPNGBDBM482289(US10918645, Example 84 | 1-isopropyl-9-(1-(2-metho...)
Affinity DataIC50: 46nMAssay Description:TTBK1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 1 mg/ml BSA, 10 mM DTT) is assayed against RRKDLHDDEEDEAMSITA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Lifearc

US Patent
LigandPNGBDBM482289(US10918645, Example 84 | 1-isopropyl-9-(1-(2-metho...)
Affinity DataIC50: 9.90E+3nMAssay Description:JAK2 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.05% 0-mercaptoethanol, 1 mg/ml BSA) is assayed against PDKtide (KTFCGTPEYLAPEVRREPRILSEEEQ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
US Patent