BDBM483387 US10919911, Example 9

SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nncn3C(C)(C)COc12

InChI Key InChIKey=RNCDOTHGSYLQCU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 483387   

LigandPNGBDBM483387(US10919911, Example 9)
Affinity DataIC50: 5.60nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
US Patent

LigandPNGBDBM483387(US10919911, Example 9)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed