BDBM483809 (R)-1-(2-methyl-4- (2-(pyrrolidin-1-yl)- 4-(trifluoromethyl)- benzyl)- piperazine-1- carbonyl)-1H- pyrazole-3- carboxylic acid::US10927105, Ex 327::US11655217, Example 327

SMILES C[C@@H]1CN(Cc2ccc(cc2N2CCCC2)C(F)(F)F)CCN1C(=O)n1ccc(n1)C(O)=O

InChI Key InChIKey=LOZHXFCOGJLKLL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 483809   

TargetMonoglyceride lipase(Human)
Lundbeck La Jolla Research Center

US Patent
LigandPNGBDBM483809(US10927105, Ex 327 | (R)-1-(2-methyl-4- (2-(pyrrol...)
Affinity DataIC50: 100nMAssay Description:Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Lundbeck La Jolla Research Center

US Patent
LigandPNGBDBM483809(US10927105, Ex 327 | (R)-1-(2-methyl-4- (2-(pyrrol...)
Affinity DataIC50: 100nMAssay Description:Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent