BDBM483832 1-(4-(2-((2R,5R)- 2,5- dimethylpyrrolidin- 1-yl)-4- (trifluoromethyl)- benzyl)piperazine- 1-carbonyl)-1H- pyrazole-3- carboxylic acid::US10927105, Ex 359::US11655217, Example 359

SMILES C[C@@H]1CC[C@@H](C)N1c1cc(ccc1CN1CCN(CC1)C(=O)n1ccc(n1)C(O)=O)C(F)(F)F

InChI Key InChIKey=CUSMRMZYSSKRQO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 483832   

TargetMonoglyceride lipase(Human)
H. Lundbeck

US Patent
LigandPNGBDBM483832(US10927105, Ex 359 | 1-(4-(2-((2R,5R)- 2,5- dimeth...)
Affinity DataIC50: 100nMAssay Description:Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
H. Lundbeck

US Patent
LigandPNGBDBM483832(US10927105, Ex 359 | 1-(4-(2-((2R,5R)- 2,5- dimeth...)
Affinity DataIC50: 100nMAssay Description:Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
US Patent