BDBM483849 4-chloro-1-(2-(3- chloro-5- (trifluoromethyl)- benzyl)-2,8- diazaspiro- [4.5]decane-8- carbonyl)-1H- pyrazole-3- carboxylic acid::US10927105, Ex 388::US11655217, Example 388

SMILES OC(=O)c1nn(cc1Cl)C(=O)N1CCC2(CCN(Cc3cc(Cl)cc(c3)C(F)(F)F)C2)CC1

InChI Key InChIKey=TXLHOHAELHUJLS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 483849   

TargetMonoglyceride lipase(Human)
H. Lundbeck

US Patent
LigandPNGBDBM483849(US10927105, Ex 388 | 4-chloro-1-(2-(3- chloro-5- (...)
Affinity DataIC50: 100nMAssay Description:Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
H. Lundbeck

US Patent
LigandPNGBDBM483849(US10927105, Ex 388 | 4-chloro-1-(2-(3- chloro-5- (...)
Affinity DataIC50: 100nMAssay Description:Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
US Patent