BDBM483852 1-(2-(5-(pyrrolidin- 1-yl)-2- (trifluoromethyl)- benzyl)-2,8- diazaspiro[4.5]- decane-8- carbonyl)-1H- pyrazole-3- carboxylic acid::US10927105, Ex 391::US11655217, Example 391

SMILES OC(=O)c1ccn(n1)C(=O)N1CCC2(CCN(Cc3cc(ccc3C(F)(F)F)N3CCCC3)C2)CC1

InChI Key InChIKey=KMXOWOWFWQYDBH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 483852   

TargetMonoglyceride lipase(Human)
H. Lundbeck

US Patent
LigandPNGBDBM483852(US10927105, Ex 391 | 1-(2-(5-(pyrrolidin- 1-yl)-2-...)
Affinity DataIC50: 100nMAssay Description:Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
H. Lundbeck

US Patent
LigandPNGBDBM483852(US10927105, Ex 391 | 1-(2-(5-(pyrrolidin- 1-yl)-2-...)
Affinity DataIC50: 100nMAssay Description:Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
US Patent