BDBM484737 US10934297, Compound 150::US11713320, Compound 150

SMILES Cn1cc(cn1)-c1cc2c(n[nH]c2cc1F)C(=O)Nc1cccc(OC2CCNCC2)c1

InChI Key InChIKey=WYBZKFYOHMJRII-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 484737   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Biosplice Therapeutics

US Patent
LigandPNGBDBM484737(US10934297, Compound 150 | US11713320, Compound 15...)
Affinity DataEC50:  4nMAssay Description:Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
US Patent

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Biosplice Therapeutics

US Patent
LigandPNGBDBM484737(US10934297, Compound 150 | US11713320, Compound 15...)
Affinity DataEC50:  4nMAssay Description:DYRK1A: Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Biosplice Therapeutics

US Patent
LigandPNGBDBM484737(US10934297, Compound 150 | US11713320, Compound 15...)
Affinity DataEC50:  52nMAssay Description:Each compound is dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Biosplice Therapeutics

US Patent
LigandPNGBDBM484737(US10934297, Compound 150 | US11713320, Compound 15...)
Affinity DataEC50:  52nMAssay Description:GSK3β: Each compound is dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-respo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent