BDBM484836 US10934302, Example 87

SMILES N[C@@H]1c2ccccc2CC11CCN(CC1)c1cnc(Sc2ccnc(N)c2Cl)c(N)n1

InChI Key InChIKey=OSKLARGYVMOWIX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 484836   

LigandPNGBDBM484836(US10934302, Example 87)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to SHP2 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM484836(US10934302, Example 87)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of LN(pY)IDLDLV(dPEG8)LST(pY)ASINFQKASINFQK-NH2-activated SHP2 (unknown origin) using DiFMUP as substrate pretreated with enzyme for 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM484836(US10934302, Example 87)
Affinity DataIC50: 4nMAssay Description:Allosteric inhibition of dPEG8 peptide-activated SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 followed by substrate addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSH2B adapter protein 2(Human)
Relay Therapeutics

US Patent
LigandPNGBDBM484836(US10934302, Example 87)
Affinity DataIC50: 50nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent