BDBM486450 (R,Z)-6-(2-(3-(2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10947223, Example 114

SMILES C[C@@]1(N=C(N)OCC1(F)F)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F

InChI Key InChIKey=VGRLDTRYWIJIQU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 486450   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM486450((R,Z)-6-(2-(3-(2-amino-5,5-difluoro-4-methyl-5,6-d...)
Affinity DataIC50: 256nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM486450((R,Z)-6-(2-(3-(2-amino-5,5-difluoro-4-methyl-5,6-d...)
Affinity DataIC50: 2.66E+3nMAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetBeta-secretase 2(Mouse)
Amgen

US Patent
LigandPNGBDBM486450((R,Z)-6-(2-(3-(2-amino-5,5-difluoro-4-methyl-5,6-d...)
Affinity DataIC50: 2.73E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetCathepsin D(Human)
Amgen

US Patent
LigandPNGBDBM486450((R,Z)-6-(2-(3-(2-amino-5,5-difluoro-4-methyl-5,6-d...)
Affinity DataIC50: 4.00E+5nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent