BDBM487329 US10947254, Example 6-8::US11780852, Example 6-8

SMILES Cc5cnc4cc(Nc1cc(C)[nH]n1)nc(N[C@H]2C[C@@H]3CCC[C@H](C2)N3S(C)(=O)=O)c4c5

InChI Key InChIKey=AZRKJKTXTSDBDW-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 487329   

TargetTyrosine-protein kinase JAK2(Human)
Theravance Biopharma R&D IP

US Patent
LigandChemical structure of BindingDB Monomer ID 487329BDBM487329(US10947254, Example 6-8 | US11780852, Example 6-8 ...)
Affinity DataKi: <0.100nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Theravance Biopharma R&D IP

US Patent
LigandChemical structure of BindingDB Monomer ID 487329BDBM487329(US10947254, Example 6-8 | US11780852, Example 6-8 ...)
Affinity DataKi:  0.550nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Theravance Biopharma R&D IP

US Patent
LigandChemical structure of BindingDB Monomer ID 487329BDBM487329(US10947254, Example 6-8 | US11780852, Example 6-8 ...)
Affinity DataKi:  0.550nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Theravance Biopharma R&D IP

US Patent
LigandChemical structure of BindingDB Monomer ID 487329BDBM487329(US10947254, Example 6-8 | US11780852, Example 6-8 ...)
Affinity DataKi:  0.550nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent