BDBM487358 (E)-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-3-(isopropylamino)prop-1-ene-1-sulfonamide::US12599616, Example 1

SMILES CC(C)NC/C=C/S(=O)(=O)NC(=O)Nc1c2c(cc3c1CCC3)CCC2

InChI Key InChIKey=IOXHDCKPPIFZBL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 487358   

TargetInterleukin-1 beta(Human)
Zydus Lifesciences

US Patent
LigandChemical structure of BindingDB Monomer ID 487358BDBM487358((E)-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carba...)
Affinity DataIC50: 43nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent