BDBM487395 (E)-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-3-(pyrrolidin-1-yl)prop-1-ene-1-sulfonamide::US12599616, Example 18

SMILES O=C(Nc1c2c(cc3c1CCC3)CCC2)NS(=O)(=O)/C=C/CN1CCCC1

InChI Key InChIKey=ACJLQRMQBHQLHF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 487395   

TargetInterleukin-1 beta(Human)
Zydus Lifesciences

US Patent
LigandChemical structure of BindingDB Monomer ID 487395BDBM487395((E)-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carba...)
Affinity DataIC50: 6.60nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent