BDBM487736 1-(1-oxo-1,2-dihydroisoquinolin- 5-yl)-5-(trifluoromethyl)-N-(2- (trifluoromethyl)pyridin-4-yl)- 1H-pyrazole-4-carboxamide::US10954214, Compound 158

SMILES FC(F)(F)c1c(cnn1-c1cccc2c1cc[nH]c2=O)C(=O)Nc1ccnc(c1)C(F)(F)F

InChI Key InChIKey=APWRZPQBPCAXFP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 487736   

TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM487736(1-(1-oxo-1,2-dihydroisoquinolin- 5-yl)-5-(trifluor...)
Affinity DataIC50: 74nMAssay Description:MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent

TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM487736(1-(1-oxo-1,2-dihydroisoquinolin- 5-yl)-5-(trifluor...)
Affinity DataIC50: 531nMAssay Description:1.1 Experimental PurposeAc-LRSR-AMC was used as the substrate to test the IC50 of the inhibitory activity of compounds on MALT1 enzyme activity at th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent