BDBM488234 2-(3-(3-(1H-benzo[d]imidazol- 2-yl)phenyl)-5- (cyclopropylmethyl)-4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1-yl)thiazole-4- carboxylic acid::US10954228, Compound 189::US10954228, Compound 221::US11752138, Compound 221

SMILES NS(=O)(=O)c1ccc(Cc2c(CC3CC3)n(nc2-c2cccc(c2)-c2nc3ccccc3[nH]2)-c2nc(cs2)C(O)=O)cc1F

InChI Key InChIKey=ZQHDGXQMMOIECU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 488234   

TargetL-lactate dehydrogenase A chain(Human)
The Trustees of The University of Pennsylvania

US Patent
LigandPNGBDBM488234(US10954228, Compound 221 | 2-(3-(3-(1H-benzo[d]imi...)
Affinity DataIC50: 100nMAssay Description:Test compounds were placed in a Greiner Bio-One (Monroe, N.C.) 1536-well black solid bottom assay plate. 200 millimolar (mM) Tris HCl, pH 7.4, 100 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent

TargetL-lactate dehydrogenase A chain(Human)
The Trustees of The University of Pennsylvania

US Patent
LigandPNGBDBM488234(US10954228, Compound 221 | 2-(3-(3-(1H-benzo[d]imi...)
Affinity DataIC50: 100nMAssay Description:Test compounds were placed in a Greiner Bio-One (Monroe, N.C.) 1536-well black solid bottom assay plate. 200 millimolar (mM) Tris HCl, pH 7.4, 100 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent

TargetL-lactate dehydrogenase B chain(Human)
Vanderbilt University

US Patent
LigandPNGBDBM488234(US10954228, Compound 221 | 2-(3-(3-(1H-benzo[d]imi...)
Affinity DataIC50: 100nMAssay Description:This example describes a human LDHB biochemical assay employed in the characterization of a compound of Formula I in an embodiment of the dislcosure....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2023
Entry Details
US Patent

TargetL-lactate dehydrogenase B chain(Human)
Vanderbilt University

US Patent
LigandPNGBDBM488234(US10954228, Compound 221 | 2-(3-(3-(1H-benzo[d]imi...)
Affinity DataIC50: 100nMAssay Description:This example describes a human LDHB biochemical assay employed in the characterization of a compound of Formula I in an embodiment of the dislcosure....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2023
Entry Details
US Patent