BDBM488288 2-(5-(2-cyclopropylethyl)- 4-(3-fluoro-4-sulfamoylbenzyl)- 3-(3-((2-methylthiazol-4- yl)ethynyl)phenyl)-1H- pyrazol-1-yl)thiazole-4- carboxylic acid::US10954228, Compound 243::US11752138, Compound 243
SMILES Cc1nc(cs1)C#Cc1cccc(c1)-c1nn(c(CCC2CC2)c1Cc1ccc(c(F)c1)S(N)(=O)=O)-c1nc(cs1)C(O)=O
InChI Key InChIKey=OTIUTWXEDPMFQX-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 488288
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
The Trustees of The University of Pennsylvania
US Patent
The Trustees of The University of Pennsylvania
US Patent
Affinity DataIC50: <100nMAssay Description:Test compounds were placed in a Greiner Bio-One (Monroe, N.C.) 1536-well black solid bottom assay plate. 200 millimolar (mM) Tris HCl, pH 7.4, 100 mi...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
The Trustees of The University of Pennsylvania
US Patent
The Trustees of The University of Pennsylvania
US Patent
Affinity DataIC50: 90nMAssay Description:Inhibition of GS[HiBiT]GS-tagged LDHA (unknown origin) expressed in HEK-293T cells measured after 1 hr by CESTAMore data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:This example describes a human LDHB biochemical assay employed in the characterization of a compound of Formula I in an embodiment of the dislcosure....More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
The Trustees of The University of Pennsylvania
US Patent
The Trustees of The University of Pennsylvania
US Patent
Affinity DataIC50: 300nMAssay Description:Inhibition of LDHA in human A673 cells assessed as decrease in lactate production incubated for 2 hrs by lactate oxidase-coupled fluorescence based a...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
The Trustees of The University of Pennsylvania
US Patent
The Trustees of The University of Pennsylvania
US Patent
Affinity DataIC50: 253nMAssay Description:Inhibition of LDHA in human MIA PaCa-2 cells assessed as decrease in lactate production incubated for 2 hrs by lactate oxidase-coupled fluorescence b...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
The Trustees of The University of Pennsylvania
US Patent
The Trustees of The University of Pennsylvania
US Patent
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant human LDHA using sodium pyruvate as substrate preincubated for 5 mins followed by diaphorase/resazurin addition and measure...More data for this Ligand-Target Pair