BDBM488663 (R)-N-(3-(2-(3- (ethylsulfonyl)-2- fluorophenylamino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)propanamide::US10961228, Example 3

SMILES CCS(=O)(=O)c1cccc(Nc2ncc(C)c(n2)-c2c[nH]c3c(NC(=O)[C@@H](C)N4CCN(C)CC4)cccc23)c1F

InChI Key InChIKey=RDUQTVRIGVNMLI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 488663   

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488663(US10961228, Example 3 | (R)-N-(3-(2-(3- (ethylsulf...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandPNGBDBM488663(US10961228, Example 3 | (R)-N-(3-(2-(3- (ethylsulf...)
Affinity DataIC50: 4.12E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Astrazeneca

US Patent
LigandPNGBDBM488663(US10961228, Example 3 | (R)-N-(3-(2-(3- (ethylsulf...)
Affinity DataIC50: 3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent