BDBM488690 (R)-N-(3-(5-fluoro-2- ((2-fluoro-3- methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7-yl)-2- (4-methyl-1,4-diazepan- 1-yl)butanamide::US10961228, Example 17

SMILES CC[C@@H](N1CCCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F

InChI Key InChIKey=PUUJLIQLJNLBPS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 488690   

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488690(US10961228, Example 17 | (R)-N-(3-(5-fluoro-2- ((2...)
Affinity DataIC50: 3.60nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandPNGBDBM488690(US10961228, Example 17 | (R)-N-(3-(5-fluoro-2- ((2...)
Affinity DataIC50: 4.86E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Astrazeneca

US Patent
LigandPNGBDBM488690(US10961228, Example 17 | (R)-N-(3-(5-fluoro-2- ((2...)
Affinity DataIC50: 3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent