BDBM488829 2-(3-([1,1'-biphenyl]- 3-yl)-5-((2,2- difluorocyclopropyl) methyl)-4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid::US10961200, Compound 207::US11247971, Cmpd ID 207

SMILES NS(=O)(=O)c1ccc(Cc2c(CC3CC3(F)F)n(nc2-c2cccc(c2)-c2ccccc2)-c2nc(cs2)C(O)=O)cc1

InChI Key InChIKey=MMETUHAMLMUZQF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 488829   

TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM488829(US10961200, Compound 207 | 2-(3-([1,1'-biphenyl]- ...)
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human LDHA using sodium pyruvate as substrate preincubated for 5 mins followed by diaphorase/resazurin addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM488829(US10961200, Compound 207 | 2-(3-([1,1'-biphenyl]- ...)
Affinity DataIC50: 100nMAssay Description:Test compounds were placed in a Greiner Bio-One (Monroe, N.C.) 1536-well black solid bottom assay plate. 200 millimolar (mM) Tris HCl, pH 7.4, 100 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM488829(US10961200, Compound 207 | 2-(3-([1,1'-biphenyl]- ...)
Affinity DataIC50: 501nMAssay Description:Inhibition of GS[HiBiT]GS-tagged LDHA (unknown origin) expressed in HEK-293T cells measured after 1 hr by CESTAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM488829(US10961200, Compound 207 | 2-(3-([1,1'-biphenyl]- ...)
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of LDHA in human A673 cells assessed as decrease in lactate production incubated for 2 hrs by lactate oxidase-coupled fluorescence based a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM488829(US10961200, Compound 207 | 2-(3-([1,1'-biphenyl]- ...)
Affinity DataIC50: 1.72E+3nMAssay Description:Inhibition of LDHA in human MIA PaCa-2 cells assessed as decrease in lactate production incubated for 2 hrs by lactate oxidase-coupled fluorescence b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed