BDBM491184 2-(4-Chlorophenyl)-2-((3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-yl)thio)acetamide::US10975056, Example 128::US11771711, Reference compound 3

SMILES CCc1c(C#N)c(SC(C(N)=O)c2ccc(Cl)cc2)nc(N(C)C)c1C#N

InChI Key InChIKey=STOCLPJPNSTUAB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 491184   

TargetDNA (cytosine-5)-methyltransferase 1 [601-1600](Human)
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM491184(US10975056, Example 128 | 2-(4-Chlorophenyl)-2-((3...)
Affinity DataIC50: 631nMAssay Description:This assay used Scintillation Proximity technology in a signal increase format to evaluate the potency of compounds. Human truncated DNMT1(601-1600),...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2023
Entry Details
US Patent

TargetDNA (cytosine-5)-methyltransferase 1(Human)
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM491184(US10975056, Example 128 | 2-(4-Chlorophenyl)-2-((3...)
Affinity DataIC50: 660nMAssay Description:Biochemical activity of DNMT1 analyzed using SPA technology. Plates (Griener 784075) were pre-stamped with 100 nL/well of compound (11-point, 3-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent