BDBM492388 US10975080, Example 85::US12053470, Compound 39

SMILES C[C@@H]1OCC2(CCN(CC2)c2cnc3c(n[nH]c3n2)-c2ccnc(Cl)c2Cl)[C@@H]1N

InChI Key InChIKey=FDSVUVZQRZMZJD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 492388   

LigandPNGBDBM492388(US10975080, Example 85 | US12053470, Compound 39)
Affinity DataIC50: 67nMAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
US Patent

LigandPNGBDBM492388(US10975080, Example 85 | US12053470, Compound 39)
Affinity DataIC50: 67nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent