BDBM492697 Preparation of 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((5-(2-methoxyeth oxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinoline-10-yl)oxy)phenyl)urea::US10980809, Example 93::US11479559, Example 8

SMILES COCCOc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2c2OCCOc12

InChI Key InChIKey=TYGJCKOCYFNCES-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 492697   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM492697(Preparation of 1-(4-chloro-3-(trifluoromethyl)phen...)
Affinity DataIC50: 50nMAssay Description:The assay is based on the LANCE TR-FRET technology of Perkin Elmer Inc., and the assay method is as follows:1. Dilution of compounds: a total of 11 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM492697(Preparation of 1-(4-chloro-3-(trifluoromethyl)phen...)
Affinity DataIC50: 275nMAssay Description:The assay is based on the LANCE TR-FRET technology of Perkin Elmer Inc., and the assay method is as follows:1. Dilution of compounds: a total of 11 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM492697(Preparation of 1-(4-chloro-3-(trifluoromethyl)phen...)
Affinity DataIC50: 275nMAssay Description:1. Dilution of the compound: a total of 12 concentrations were obtained using a 4-fold gradient dilution from the highest concentration of 10000 nM (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent