BDBM493071 2-((1r,4r)-4-(2-(2-(4-Hydroxypiperidin-1-yl)-2-oxoethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 12

SMILES OC1CCN(CC1)C(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 493071   

TargetTyrosine-protein kinase JAK1 [574-1154](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM493071(2-((1r,4r)-4-(2-(2-(4-Hydroxypiperidin-1-yl)-2-oxo...)
Affinity DataIC50:  0.100nMAssay Description:11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182,C936A,C1142A](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM493071(2-((1r,4r)-4-(2-(2-(4-Hydroxypiperidin-1-yl)-2-oxo...)
Affinity DataIC50:  1.40nMAssay Description:11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3 [512-1124](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM493071(2-((1r,4r)-4-(2-(2-(4-Hydroxypiperidin-1-yl)-2-oxo...)
Affinity DataIC50:  99.4nMAssay Description:11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [532-1132](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM493071(2-((1r,4r)-4-(2-(2-(4-Hydroxypiperidin-1-yl)-2-oxo...)
Affinity DataIC50:  9.20nMAssay Description:11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent