BDBM493082 US10981914, Compound Ia-03

SMILES CCCCOc1nc(N)c2nc(O)n(Cc3ccc4N(C)c5ccc(CNc6ccccc6)cc5Sc4c3)c2n1

InChI Key InChIKey=JWPFYRJMXARJSW-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 493082   

TargetInterleukin-6(Human)
Bristol-Myers Squibb Companay

US Patent
LigandPNGBDBM493082(US10981914, Compound Ia-03)
Affinity DataEC50:  14.4nMAssay Description:Compounds diluted in DMSO were transferred to individual wells of a Matrix Technologies clear, V-bottom 384-well plate using ECHO acoustic liquid han...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetToll-like receptor 7(Human)
Bristol-Myers Squibb Companay

US Patent
LigandPNGBDBM493082(US10981914, Compound Ia-03)
Affinity DataEC50:  8.5nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent