BDBM493609 US10988445, Example 205

SMILES COC1(CC(=O)N2Cc3cc(ccc3C2C(=O)Nc2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)CC2CC2)CC1

InChI Key InChIKey=PBADGIYXWFABFU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 493609   

TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

US Patent
LigandPNGBDBM493609(US10988445, Example 205)
Affinity DataIC50: 20nMAssay Description:The assay was run in black 384 well plates (Greiner cat no: 784900). Various concentrations of test ligands in 0.1 microlitres DMSO were dispensed to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

US Patent
LigandPNGBDBM493609(US10988445, Example 205)
Affinity DataIC50: 126nMAssay Description:The scintillation proximity assay (SPA) was run in white polystyrene flat-bottom 384-well plates (Greiner, cat. No. 781075). Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent