BDBM493612 US10988445, Example 208

SMILES OC(c1ccc(NC(=O)C2N(Cc3cc(ccc23)S(=O)(=O)CC2CC2)C(=O)C2CCCO2)cc1)(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=YAXGXFXDGCKUOK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 493612   

TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

US Patent
LigandPNGBDBM493612(US10988445, Example 208)
Affinity DataIC50: 31.6nMAssay Description:The assay was run in black 384 well plates (Greiner cat no: 784900). Various concentrations of test ligands in 0.1 microlitres DMSO were dispensed to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

US Patent
LigandPNGBDBM493612(US10988445, Example 208)
Affinity DataIC50: 100nMAssay Description:The scintillation proximity assay (SPA) was run in white polystyrene flat-bottom 384-well plates (Greiner, cat. No. 781075). Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent