BDBM493623 US10988445, Example 303

SMILES CC[C@@H](O)C(=O)N1Cc2cc(ccc2C1C(=O)Nc1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)NC

InChI Key InChIKey=KUZGDGCLYCSHNU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 493623   

TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

US Patent
LigandPNGBDBM493623(US10988445, Example 303)
Affinity DataIC50: 39.8nMAssay Description:The assay was run in black 384 well plates (Greiner cat no: 784900). Various concentrations of test ligands in 0.1 microlitres DMSO were dispensed to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

US Patent
LigandPNGBDBM493623(US10988445, Example 303)
Affinity DataIC50: 126nMAssay Description:The scintillation proximity assay (SPA) was run in white polystyrene flat-bottom 384-well plates (Greiner, cat. No. 781075). Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

US Patent
LigandPNGBDBM493623(US10988445, Example 303)
Affinity DataIC50: 126nMAssay Description:The assay was run in black 384 well plates (Greiner cat no: 784900). Various concentrations of test ligands in 0.1 microlitres DMSO were dispensed to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

US Patent
LigandPNGBDBM493623(US10988445, Example 303)
Affinity DataIC50: 501nMAssay Description:The scintillation proximity assay (SPA) was run in white polystyrene flat-bottom 384-well plates (Greiner, cat. No. 781075). Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent