BDBM493757 US10988455, Example 1(xcv)
SMILES Cc1cc(cc(Cl)n1)-c1nnc(N)nc1-c1ccc(F)cc1
InChI Key InChIKey=NCWQLHHDGDXIJN-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 493757
Affinity DataKi: 1.70nMAssay Description:Antagonist activity at adenosine A2A receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Displacement of [3H]ZM241385 from human A2AAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by ...More data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Binding affinity to human adenosine A2A receptor assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 13.8nMAssay Description:All test compounds were prepared as a stock solution of 10 mM in 100% DMSO.Inhibition binding assays were performed using 2.5 μg of membranes pr...More data for this Ligand-Target Pair
Affinity DataKi: 56nMAssay Description:Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H...More data for this Ligand-Target Pair
Affinity DataKi: 131nMAssay Description:Displacement of [3H]DPCPX from human A1AR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]...More data for this Ligand-Target Pair
Affinity DataKi: 214nMAssay Description:All test compounds were prepared as a stock solution of 10 mM in 100% DMSO.Inhibition binding assays were performed using 2.5 μg of membranes pr...More data for this Ligand-Target Pair
Affinity DataKi: 2.27E+4nMAssay Description:Displacement of [3H]HEMADO from human A3AR expressed in CHO-K1 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H...More data for this Ligand-Target Pair
Affinity DataIC50: 299nMAssay Description:Antagonist activity at A2AAR in human HEK293 cells assessed as inhibition of CGS21680-induced cAMP production preincubated for 15 mins followed by CG...More data for this Ligand-Target Pair
Affinity DataEC50: 725nMAssay Description:Antagonist activity at A2AAR in human T -cells assessed as increase in IL-2 production preincubated for 1 hr followed by CD3/CD28 monoclonal antibody...More data for this Ligand-Target Pair