BDBM493844 US10988458, Example 51a::US11560368, Example 51a

SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cn2)-n2cnc(c2)C(F)(F)F)n1

InChI Key InChIKey=HYGBAWGNPUEXMV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 493844   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Enanta Pharmaceuticals

US Patent
LigandPNGBDBM493844(US10988458, Example 51a | US11560368, Example 51a)
Affinity DataIC50: 5.5nMAssay Description:ASK1 was purchased from Thermofisher (Catalogue #PV4011), ATP was purchased from Sigma (Catalogue #A7699), HTRF KinEASE Assay System was obtained fro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Enanta Pharmaceuticals

US Patent
LigandPNGBDBM493844(US10988458, Example 51a | US11560368, Example 51a)
Affinity DataIC50: 5.5nMAssay Description:ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF KinEASE Assay System was obtained f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent