BDBM497080 US11001561, Compound 67b::US11702392, Compound 67b

SMILES Cc1c(N2CCC3(CCC[C@@H]3N)CC2)nc(C)n(-c2cccc(Cl)c2Cl)c1=O

InChI Key InChIKey=CTOJEWHBDDECEU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 497080   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497080BDBM497080(US11001561, Compound 67b | US11702392, Compound 67...)
Affinity DataIC50: 41nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497080BDBM497080(US11001561, Compound 67b | US11702392, Compound 67...)
Affinity DataIC50: 41nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent