BDBM497128 US11001561, Compound 103::US11702392, Compound 103

SMILES Cc1c(F)ccc(-n2c(C)nc(N3CCC4(CC3)CO[C@@H](C)[C@H]4N)c(C)c2=O)c1Cl

InChI Key InChIKey=DHQOXCOJBKARIN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 497128   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497128BDBM497128(US11001561, Compound 103 | US11702392, Compound 10...)
Affinity DataIC50: 67nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497128BDBM497128(US11001561, Compound 103 | US11702392, Compound 10...)
Affinity DataIC50: 67nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent