BDBM497394 US11008301, Example 9

SMILES FC(F)(F)c1ccc(NC(=O)N[C@H]2CCCN(C2=O)c2ccc(cc2)N2CC3(COC3)C2)cc1

InChI Key InChIKey=NJWSIQJYGLUKAM-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 497394   

TargetN-formyl peptide receptor 2(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM497394(US11008301, Example 9)
Affinity DataEC50:  540nMAssay Description:Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetN-formyl peptide receptor 2(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM497394(US11008301, Example 9)
Affinity DataEC50:  540nMAssay Description:FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetfMet-Leu-Phe receptor(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM497394(US11008301, Example 9)
Affinity DataEC50:  1.50E+3nMAssay Description:FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetfMet-Leu-Phe receptor(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM497394(US11008301, Example 9)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed