BDBM497562 (1S,8R)-5-(2,6-difluorophenyl)-11,11- dimethyl-1-[6-[1-(2- methylsulfonylethyl)pyrazol-3-yl]pyrazin- 2-yl]-3,4-diazatricyclo[6.2.1.02,7]undeca- 2(7),3,5-triene::US11008312, Example 59

SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cncc(n1)-c1ccn(CCS(C)(=O)=O)n1

InChI Key InChIKey=LJYFGQRSBUGVHL-SOKVYYICSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 497562   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM497562((1S,8R)-5-(2,6-difluorophenyl)-11,11- dimethyl-1-[...)
Affinity DataIC50:  4.60nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent