BDBM497855 (5R,8S)-8-(6-(3-(difluoromethyl)-1H- 1,2,4-triazol-1-yl)pyridin-2-yl)-3-(2,6- difluorophenyl)-9,9-dimethyl-5,6,7,8- tetrahydro-5,8-methanocinnoline::US11008312, Example 327

SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cccc(n1)-n1cnc(n1)C(F)F

InChI Key InChIKey=XMVQVRZJNXVNMU-SXBQZSJRSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 497855   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM497855((5R,8S)-8-(6-(3-(difluoromethyl)-1H- 1,2,4-triazol...)
Affinity DataIC50:  3.10nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent