BDBM498094 2-(6-(((1R,2S)-2-((E)-1-phenylbut-1-en-2-yl)cyclopropyl)amino)-2-azaspiro[3.3]heptan-2-yl)ethanesulfonamide::US11013718, Compound 32

SMILES CC\C(=C/c1ccccc1)[C@@H]1C[C@H]1N(C1CC2(C1)CN(CCS(N)(=O)=O)C2)C(=O)C(F)(F)F

InChI Key InChIKey=ZPZBRGQTLNNERR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 498094   

TargetLysine-specific histone demethylase 1A(Human)
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM498094(2-(6-(((1R,2S)-2-((E)-1-phenylbut-1-en-2-yl)cyclop...)
Affinity DataIC50: 100nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
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Date in BDB:
11/22/2021
Entry Details
US Patent