BDBM498321 US11014911, Example 146::US11718603, Example 146

SMILES COc1cc(CC(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)N2CCC2(C)C)ccn1

InChI Key InChIKey=JLYDSXZEVTUEGH-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 498321   

LigandPNGBDBM498321(US11014911, Example 146 | US11718603, Example 146)
Affinity DataKi:  0.0700nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

LigandPNGBDBM498321(US11014911, Example 146 | US11718603, Example 146)
Affinity DataKi:  0.0700nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498321(US11014911, Example 146 | US11718603, Example 146)
Affinity DataKi:  3.47nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498321(US11014911, Example 146 | US11718603, Example 146)
Affinity DataKi:  3.47nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
US Patent