BDBM498719 (1S,3R)-3-(3-{[(2- methylpyridin-4- yl)acetyl]amino}-1H-pyrazol-5- yl)cyclopentyl (cis-4- hydroxycyclohexyl)carbamate::US11014911, Example 544::US11718603, Example 544

SMILES Cc1cc(CC(=O)Nc2cc([nH]n2)[C@@H]2CC[C@@H](C2)OC(=O)N[C@@H]2CC[C@H](O)CC2)ccn1

InChI Key

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 498719   

LigandPNGBDBM498719((1S,3R)-3-(3-{[(2- methylpyridin-4- yl)acetyl]am...)
Affinity DataKi:  0.540nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


LigandPNGBDBM498719((1S,3R)-3-(3-{[(2- methylpyridin-4- yl)acetyl]am...)
Affinity DataKi:  0.540nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498719((1S,3R)-3-(3-{[(2- methylpyridin-4- yl)acetyl]am...)
Affinity DataKi:  1.96nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498719((1S,3R)-3-(3-{[(2- methylpyridin-4- yl)acetyl]am...)
Affinity DataKi:  1.96nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent