BDBM499102 US11014963, Example 13::US11014963, Example 14

SMILES COc1ccc(cc1)[C@H](NC(=O)[C@H](Cc1ccccc1C#N)NC(=O)c1ccccn1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F

InChI Key InChIKey=GCPVZBQKNVCOHO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 499102   

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499102(US11014963, Example 14 | US11014963, Example 13)
Affinity DataIC50: 1.10nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM499102(US11014963, Example 14 | US11014963, Example 13)
Affinity DataIC50: 4.90nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent