BDBM499813 (2-chloro-4-phenoxyphenyl)(4- (((3R,6R)-6-(hydroxymethyl)tetrahydro- 2H-pyran-3-yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5-yl)methanone::US11020398, Compound I-125

SMILES OC[C@H]1CC[C@H](CO1)Nc1ncnc2[nH]cc(C(=O)c3ccc(Oc4ccccc4)cc3Cl)c12

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 499813   

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499813((2-chloro-4-phenoxyphenyl)(4- (((3R,6R)-6-(hydroxy...)
Affinity DataIC50:  0.560nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetTyrosine-protein kinase BTK [C481S](Human)
Arqule

US Patent
LigandPNGBDBM499813((2-chloro-4-phenoxyphenyl)(4- (((3R,6R)-6-(hydroxy...)
Affinity DataIC50:  0.370nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499813((2-chloro-4-phenoxyphenyl)(4- (((3R,6R)-6-(hydroxy...)
Affinity DataIC50:  0.560nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent