BDBM50007456 1-[4-(8-Methoxy-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-ethanone::CHEMBL131155

SMILES COc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C(C)=O)CC1

InChI Key InChIKey=GBNCDPNRJULNBY-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50007456   

TargetHistamine H1 receptor(Rat)
Schering-Plough

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50007456BDBM50007456(CHEMBL131155 | 1-[4-(8-Methoxy-5,6-dihydro-benzo[5...)
Affinity DataKi:  1.60E+3nMAssay Description:Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-activating factor receptor(Human)
Schering-Plough

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50007456BDBM50007456(CHEMBL131155 | 1-[4-(8-Methoxy-5,6-dihydro-benzo[5...)
Affinity DataIC50: 3.40E+3nMAssay Description:Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when ch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50007456BDBM50007456(CHEMBL131155 | 1-[4-(8-Methoxy-5,6-dihydro-benzo[5...)
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibitory activity against recombinant human farnesyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed